Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation

详细信息    查看全文

• 作者：Jessica Segalés ; Abul B. M. M. K. Islam ; Roshan Kumar ; Qi-Cai Liu…
• 刊名：Skeletal Muscle
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：1
• 全文大小：3,186 KB
• 刊物主题：Cell Biology; Developmental Biology; Biochemistry, general; Systems Biology; Biotechnology;
• 出版者：BioMed Central
• ISSN：2044-5040

文摘

Background Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although originally identified as stress-response mediator, contributes to establishing stem cell differentiation fates. p38α is central for induction of the differentiation fate of the skeletal muscle stem cells (satellite cells) through not fully characterized mechanisms.