IDH mutations may not preclude distant, trans-tentorial spread in gliomas: a case report and review of the literature

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• 作者：Christopher S. Hong ; Jason K. Hsieh ; Nancy A. Edwards…
• 关键词：Cerebellum ; Glioma ; Isocitrate dehydrogenase ; Recurrence
• 刊名：World Journal of Surgical Oncology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：1
• 全文大小：1,517 KB
• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819

文摘

Background IDH mutations have been demonstrated to confer prolonged survival in patients suffering from gliomas, but the mechanisms underlying the improved prognosis are unclear. While some studies have attributed these observations to an enhanced sensitivity to genotoxic therapies, others have postulated that IDH-mutated gliomas exhibit less aggressive intrinsic biological behavior, including the propensity to invade distant sites. Although most gliomas recur local to the site of initial presentation, some tumors demonstrate distant recurrence, the vast majority of which involve the contralateral hemisphere. Trans-tentorial spread has been described once before, in which a supratentorial glioblastoma was reported to recur infratentorially in the cerebellum.