An experimental study of the effect of pre-operative administration of cilostazol on random skin flap survival in rats: double blinded randomized controlled trial

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• 作者：Chairat Burusapat ; Janjira Paengnoi…
• 关键词：Cilostazol ; Random skin flap in rats ; Flap survival
• 刊名：Annals of Surgical Innovation and Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：9
• 期：1
• 全文大小：2,739 KB
• 刊物主题：Surgery;
• 出版者：BioMed Central
• ISSN：1750-1164

文摘

Background Insufficient arterial blood flow is the one cause of flap necrosis. Cilostazol is an inhibitor of phosphodiesterase III and increases cyclic AMP level in vascular smooth muscle cell causing vasodilation. Therefore, effect of cilostazol is expected to improve the viability of the flap.