Antagonism between Staphylococcus epidermidis and Propionibacterium acnes and its genomic basis

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• 作者：Gitte J. M. Christensen ; Christian F. P. Scholz ; Jan Enghild ; Holger Rohde…
• 关键词：Staphylococcus epidermidis ; Propionibacterium acnes ; Skin microbiota ; Bacterial antagonism ; Antimicrobial substance ; Bacteriocin ; epidermin ; ESAT ; 6 secretion system ; Polymorphic toxin
• 刊名：BMC Genomics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1,639 KB
• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164

文摘

Background Propionibacterium acnes and Staphylococcus epidermidis live in close proximity on human skin, and both bacterial species can be isolated from normal and acne vulgaris-affected skin sites. The antagonistic interactions between the two species are poorly understood, as well as the potential significance of bacterial interferences for the skin microbiota. Here, we performed simultaneous antagonism assays to detect inhibitory activities between multiple isolates of the two species. Selected strains were sequenced to identify the genomic basis of their antimicrobial phenotypes.