In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui)

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• 作者：Qifang Lei ; Haibo Liu ; Yong Peng ; Peigen Xiao
• 刊名：Chinese Medicine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：3,229 KB
• 刊物主题：Complementary & Alternative Medicine;
• 出版者：BioMed Central
• ISSN：1749-8546

文摘

Background Some isoquinoline alkaloids from Macleaya cordata (Willd). R. Br. (Bo Luo Hui) exhibited antibacterial, antiparasitic, antitumor, and analgesic effects. The targets of these isoquinoline alkaloids are undefined. This study aims to investigate the compound–target interaction network and potential pharmacological actions of isoquinoline alkaloids of M. cordata by reverse pharmacophore database screening.