Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

详细信息    查看全文

• 作者：Emerson M. Wickwire ; Scott G. Williams ; Thomas Roth…
• 关键词：Sleep ; Sleep disorders ; Traumatic brain injury ; Concussion ; Insomnia ; Sleep apnea
• 刊名：Neurotherapeutics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：13
• 期：2
• 页码：403-417
• 全文大小：431 KB
• 参考文献：1.Faul M, Xu L, Wald MM, Coronado V. Traumatic brain injury in the United States. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control 2010.
  2.Leo P, McCrea M. Epidemiology. In: Laskowitz D, Grant G, editors. Translational research in traumatic brain injury. Boca Raton (FL): by Taylor & Francis Group, LLC; 2016.
  3.National Center for Injury Prevention and Control. Report to Congress on Mild Traumatic Brain Injury in the United States: Steps to prevent a serious public health problem. 2003.
  4.Corrigan JD, Selassie AW, Orman JA. The epidemiology of traumatic brain injury. J Head Trauma Rehabil 2010;25:72-80.PubMed CrossRef
  5.Gerberding J. for the National Center for Injury Prevention and Control. Report to congress on mild traumatic brain injury in the United States—steps to prevent a serious public health problem. 2003.
  6.Mathias JL, Alvaro PK. Prevalence of sleep disturbances, disorders, and problems following traumatic brain injury: a meta-analysis. Sleep Med 2012;13:898-905.PubMed CrossRef
  7.Kay T, Harrington D, Adams R. American Congress of Rehabilitation Medicine, Head Injury Interdisciplinary Special Interest Group. Definition of mild traumatic brain injury. J Head Trauma Rehabil 1993;8:86-87.CrossRef
  8.Menon DK, Schwab K, Wright DW, Maas AI, Demographics and Clinical Assessment Working Group of the International and Interagency Initiative toward Common Data Elements for Research on Traumatic Brain Injury and Psychological Health. Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil 2010;91:1637-1640.PubMed CrossRef
  9.Teasdale G, Jennett B. Assessment of coma and impaired consciousness: a practical scale. Lancet 1974;304:81-84.CrossRef
  10.Management of Concussion/mTBI Working Group. VA/DoD Clinical Practice Guideline for Management of Concussion/Mild Traumatic Brain Injury. J Rehabil Res Dev 2009;46:CP1-68.CrossRef
  11.Amyot F, Arciniegas DB, Brazaitis MP, et al. A review of the effectiveness of neuroimaging modalities for the detection of traumatic brain injury. J Neurotrauma 2015;32:1693-1721.PubMed CrossRef
  12.Giza CC, Hovda DA. The new neurometabolic cascade of concussion. Neurosurgery 2014;75(Suppl. 4):S24-S33.PubMed PubMedCentral CrossRef
  13.Centers for Disease control and Prevention. What are the signs and symptoms of concussion. Available at: http://​www.​cdc.​gov/​traumaticbrainin​jury/​symptoms.​html . Accessed October 1, 2015.
  14.Jaffee MS, Winter WC, Jones CC, Ling G. Sleep disturbances in athletic concussion. Brain Inj 2015;29:221-227.PubMed CrossRef
  15.Assefa SZ, Diaz-Abad M, Wickwire EM, Scharf SM. The functions of sleep. AIMS Neuroscience 2015;2(3):155-171.
  16.Berry R, Brooks R, Gamaldo C, Harding S, Marcus C, Vaughn B. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, version 2.0. Darien, Illinois: American Academy of Sleep Medicine 2012:47.
  17.Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE. Sleep state switching. Neuron 2010;68:1023-1042.PubMed PubMedCentral CrossRef
  18.Van Dongen HP, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 2003;26:117-126.PubMed
  19.Banks S, Dinges DF. Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med 2007;3:519-528.PubMed PubMedCentral
  20.Cirelli C. Brain plasticity, sleep and aging. Gerontology 2012;58:441-445.PubMed CrossRef
  21.Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science 2013;342:373-377.PubMed CrossRef
  22.Shekleton JA, Parcell DL, Redman JR, Phipps-Nelson J, Ponsford JL, Rajaratnam SM. Sleep disturbance and melatonin levels following traumatic brain injury. Neurology 2010;74:1732-1738.PubMed PubMedCentral CrossRef
  23.Weil ZM, Norman GJ, Karelina K, et al. Sleep deprivation attenuates inflammatory responses and ischemic cell death. Exp Neurol 2009;218:129-136.PubMed PubMedCentral CrossRef
  24.Hsu JC, Lee YS, Chang CN, Ling EA, Lan CT. Sleep deprivation prior to transient global cerebral ischemia attenuates glial reaction in the rat hippocampal formation. Brain Res 2003;984:170-181.PubMed CrossRef
  25.Moldovan M, Constantinescu AO, Balseanu A, Oprescu N, Zagrean L, Popa-Wagner A. Sleep deprivation attenuates experimental stroke severity in rats. Exp Neurol 2010;222:135-143.PubMed CrossRef
  26.Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol 2009;8:398-412.PubMed PubMedCentral CrossRef
  27.Pace M, Baracchi F, Gao B, Bassetti C. Identification of sleep-modulated pathways involved in neuroprotection from stroke. Sleep 2015;38:1707-1718.PubMed CrossRef
  28.Cam E, Gao B, Imbach L, Hodor A, Bassetti CL. Sleep deprivation before stroke is neuroprotective: a pre-ischemic conditioning related to sleep rebound. Exp Neurol 2013;247:673-679.PubMed CrossRef
  29.Gao B, Cam E, Jaeger H, Zunzunegui C, Sarnthein J, Bassetti CL. Sleep disruption aggravates focal cerebral ischemia in the rat. Sleep 2010;33:879-887.PubMed PubMedCentral
  30.Zunzunegui C, Gao B, Cam E, Hodor A, Bassetti CL. Sleep disturbance impairs stroke recovery in the rat. Sleep 2011;34:1261-1269.PubMed PubMedCentral
  31.Franken P, Dijk DJ, Tobler I, Borbely AA. Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature. Am J Physiol 1991;261:R198-208.PubMed
  32.Dash MB, Douglas CL, Vyazovskiy VV, Cirelli C, Tononi G. Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states. J Neurosci 2009;29:620-629.PubMed PubMedCentral CrossRef
  33.Kong J, Shepel PN, Holden CP, Mackiewicz M, Pack AI, Geiger JD. Brain glycogen decreases with increased periods of wakefulness: implications for homeostatic drive to sleep. J Neurosci 2002;22:5581-5587.PubMed
  34.Shearer WT, Reuben JM, Mullington JM, et al. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol 2001;107:165-170.PubMed CrossRef
  35.Vgontzas AN, Zoumakis E, Bixler EO, et al. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 2004;89:2119-2126.PubMed CrossRef
  36.Hodor A, Palchykova S, Baracchi F, Noain D, Bassetti CL. Baclofen facilitates sleep, neuroplasticity, and recovery after stroke in rats. Ann Clin Transl Neurol 2014;1:765-777.PubMed PubMedCentral CrossRef
  37.Martinez-Vargas M, Estrada Rojo F, Tabla-Ramon E, et al. Sleep deprivation has a neuroprotective role in a traumatic brain injury of the rat. Neurosci Lett 2012;529:118-122.PubMed CrossRef
  38.Cheng O, Li R, Zhao L, et al. Short-term sleep deprivation stimulates hippocampal neurogenesis in rats following global cerebral ischemia/reperfusion. PLoS One 2015;10:e0125877.PubMed PubMedCentral CrossRef
  39.Ouellet MC, Beaulieu-Bonneau S, Morin CM. Insomnia in patients with traumatic brain injury: frequency, characteristics, and risk factors. J Head Trauma Rehabil 2006;21:199-212.PubMed CrossRef
  40.Gagner C, Landry-Roy C, Laine F, Beauchamp MH. Sleep–wake disturbances and fatigue after pediatric traumatic brain injury: a systematic review of the literature. J Neurotrauma 2015;32:1539-1552.PubMed CrossRef
  41.Tham SW, Fales J, Palermo TM. Subjective and objective assessment of sleep in adolescents with mild traumatic brain injury. J Neurotrauma 2015;32:847-852.PubMed CrossRef
  42.Buysse DJ, Reynolds CF,3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213.
  43.Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991;14:540-545.PubMed
  44.Masel BE, Scheibel RS, Kimbark T, Kuna ST. Excessive daytime sleepiness in adults with brain injuries. Arch Phys Med Rehabil 2001;82:1526-1532.PubMed CrossRef
  45.Lequerica A, Chiaravalloti N, Cantor J, et al. The factor structure of the Pittsburgh Sleep Quality Index in persons with traumatic brain injury. A NIDRR TBI model systems module study. NeuroRehabilitation 2014;35:485-492.PubMed
  46.Fichtenberg NL, Putnam SH, Mann NR, Zafonte RD, Millard AE. Insomnia screening in postacute traumatic brain injury: utility and validity of the Pittsburgh Sleep Quality Index. Am J Phys Med Rehabil 2001;80:339-345.CrossRef
  47.Parcell DL, Ponsford JL, Rajaratnam SM, Redman JR. Self-reported changes to nighttime sleep after traumatic brain injury. Arch Phys Med Rehabil 2006;87:278-285.PubMed CrossRef
  48.Ouellet MC, Morin CM. Efficacy of cognitive-behavioral therapy for insomnia associated with traumatic brain injury: a single-case experimental design. Arch Phys Med Rehabil 2007;88:1581-1592.PubMed CrossRef
  49.Buysse DJ, Ancoli-lsrael S, Edinger JD, Lichstein KL, Morin CM. Recommendations for a standard research assessment of insomnia. Sleep 2006;29:1155-1173.PubMed
  50.Lam JC, Mahone EM, Mason TB, Scharf SM. Defining the roles of actigraphy and parent logs for assessing sleep variables in preschool children. Behav Sleep Med 2011;9:184-193.PubMed PubMedCentral CrossRef
  51.Zollman FS, Cyborski C, Duraski SA. Actigraphy for assessment of sleep in traumatic brain injury: case series, review of the literature and proposed criteria for use. Brain Inj 2010;24:748-754.PubMed CrossRef
  52.Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak CP. The role of actigraphy in the study of sleep and circadian rhythms. Sleep 2003;26:342-392.PubMed
  53.Ayalon L, Borodkin K, Dishon L, Kanety H, Dagan Y. Circadian rhythm sleep disorders following mild traumatic brain injury. Neurology 2007;68:1136-1140.PubMed CrossRef
  54.Baumann CR, Bassetti CL, Valko PO, et al. Loss of hypocretin (orexin) neurons with traumatic brain injury. Ann Neurol 2009;66:555-559.PubMed PubMedCentral CrossRef
  55.Makley MJ, Johnson-Greene L, Tarwater PM, et al. Return of memory and sleep efficiency following moderate to severe closed head injury. Neurorehabil Neural Repair 2009;23:320-326.PubMed CrossRef
  56.Chiu HY, Lo WC, Chiang YH, Tsai PS. The effects of sleep on the relationship between brain injury severity and recovery of cognitive function: a prospective study. Int J Nurs Stud 2014;51:892-899.PubMed CrossRef
  57.Sinclair KL, Ponsford J, Rajaratnam SM. Actigraphic assessment of sleep disturbances following traumatic brain injury. Behav Sleep Med 2014;12:13-27.PubMed CrossRef
  58.Lequerica A, Jasey N, Portelli Tremont JN, Chiaravalloti ND. Pilot study on the effect of ramelteon on sleep disturbance after traumatic brain injury: preliminary evidence from a clinical trial. Arch Phys Med Rehabil 2015;96:1802-1809.PubMed CrossRef
  59.Laakso ML, Leinonen L, Lindblom N, Joutsiniemi SL, Kaski M. Wrist actigraphy in estimation of sleep and wake in intellectually disabled subjects with motor handicaps. Sleep Med 2004;5:541-550.PubMed CrossRef
  60.Rao V, Bergey A, Hill H, Efron D, McCann U. Sleep disturbance after mild traumatic brain injury: indicator of injury? J Neuropsychiatry Clin Neurosci 2011;23:201-205.PubMed CrossRef
  61.Khoury S, Chouchou F, Amzica F, et al. Rapid EEG activity during sleep dominates in mild traumatic brain injury patients with acute pain. J Neurotrauma 2013;30:633-641.PubMed CrossRef
  62.Newell J, Mairesse O, Verbanck P, Neu D. Is a one-night stay in the lab really enough to conclude? First-night effect and night-to-night variability in polysomnographic recordings among different clinical population samples. Psychiatry Res 2012;200:795-801.PubMed CrossRef
  63.Lu W, Cantor J, Aurora RN, et al. Variability of respiration and sleep during polysomnography in individuals with TBI. NeuroRehabilitation 2014;35:245-251.PubMed
  64.Plante DT, Goldstein MR, Cook JD, et al. Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: a high density EEG investigation. Clin Neurophysiol 2016;127:1436-1444.PubMed CrossRef
  65.Poryazova R, Huber R, Khatami R, et al. Topographic sleep EEG changes in the acute and chronic stage of hemispheric stroke. J Sleep Res 2015;24:54-65.PubMed CrossRef
  66.Nofzinger EA. Neuroimaging and sleep medicine. Sleep Med Rev 2005;9:157-172.PubMed CrossRef
  67.Pisarenco I, Caporro M, Prosperetti C, Manconi M. High-density electroencephalography as an innovative tool to explore sleep physiology and sleep related disorders. Int J Psychophysiol 2014;pii:S0167-8760(14)00003-8.
  68.Hasler BP, Insana SP, James JA, Germain A. Evening-type military veterans report worse lifetime posttraumatic stress symptoms and greater brainstem activity across wakefulness and REM sleep. Biol Psychol 2013;94:255-262.PubMed PubMedCentral CrossRef
  69.Germain A, James J, Insana S, et al. A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD. Psychiatry Res 2013;211:176-179.PubMed PubMedCentral CrossRef
  70.Peskind ER, Petrie EC, Cross DJ, et al. Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms. Neuroimage 2011;54(Suppl. 1):S76-S82.PubMed PubMedCentral CrossRef
  71.Stocker RP, Cieply MA, Paul B, et al. Combat-related blast exposure and traumatic brain injury influence brain glucose metabolism during REM sleep in military veterans. Neuroimage 2014;99:207-214.PubMed CrossRef
  72.Delouche A, Attye A, Heck O, et al. Diffusion MRI: Pitfalls, literature review and future directions of research in mild traumatic brain injury. Eur J Radiol 2016;85:25-30.PubMed CrossRef
  73.Currie S, Saleem N, Straiton JA, Macmullen-Price J, Warren DJ, Craven IJ. Imaging assessment of traumatic brain injury. Postgrad Med J 2016;92:41-50.PubMed
  74.Bruce ED, Konda S, Dean DD, Wang EW, Huang JH, Little DM. Neuroimaging and traumatic brain injury: State of the field and voids in translational knowledge. Mol Cell Neurosci 2015;66:103-113.PubMed CrossRef
  75.Chong CD, Schwedt TJ. White matter damage and brain network alterations in concussed patients: a review of recent diffusion tensor imaging and resting-state functional connectivity data. Curr Pain Headache Rep 2015;19:485-015-0485-0.
  76.Collen J, Orr N, Lettieri CJ, Carter K, Holley AB. Sleep disturbances among soldiers with combat-related traumatic brain injury. Chest 2012;142:622-630.PubMed CrossRef
  77.Verma A, Anand V, Verma NP. Sleep disorders in chronic traumatic brain injury. J Clin Sleep Med 2007;3:357-362.PubMed PubMedCentral
  78.Kempf J, Werth E, Kaiser PR, Bassetti CL, Baumann CR. Sleep-wake disturbances 3 years after traumatic brain injury. J Neurol Neurosurg Psychiatry 2010;81:1402-1405.PubMed CrossRef
  79.Ouellet MC, Morin CM. Subjective and objective measures of insomnia in the context of traumatic brain injury: a preliminary study. Sleep Med 2006;7:486-497.PubMed CrossRef
  80.Castriotta RJ, Wilde MC, Lai JM, Atanasov S, Masel BE, Kuna ST. Prevalence and consequences of sleep disorders in traumatic brain injury. J Clin Sleep Med 2007;3:349-356.PubMed PubMedCentral
  81.Parcell DL, Ponsford JL, Redman JR, Rajaratnam SM. Poor sleep quality and changes in objectively recorded sleep after traumatic brain injury: a preliminary study. Arch Phys Med Rehabil 2008;89:843-850.
  82.Sommerauer M, Valko PO, Werth E, Baumann CR. Excessive sleep need following traumatic brain injury: a case-control study of 36 patients. J Sleep Res 2013;22:634-639.
  83.Cote KA, Milner CE, Speth TA. Altered sleep mechanisms following traumatic brain injury and relation to waking function. AIMS Neuroscience 2015;2(4):203-228.
  84.Schreiber S, Barkai G, Gur-Hartman T, et al. Long-lasting sleep patterns of adult patients with minor traumatic brain injury (mTBI) and non-mTBI subjects. Sleep Med 2008;9:481-487.PubMed CrossRef
  85.Williams BR, Lazic SE, Ogilvie RD. Polysomnographic and quantitative EEG analysis of subjects with long-term insomnia complaints associated with mild traumatic brain injury. Clin Neurophysiol 2008;119:429-438.PubMed CrossRef
  86.Ouellet MC, Beaulieu-Bonneau S, Morin CM. Sleep-wake disturbances after traumatic brain injury. Lancet Neurol 2015;14(7):746-757.PubMed CrossRef
  87.Baumann CR, Werth E, Stocker R, Ludwig S, Bassetti CL. Sleep-wake disturbances 6 months after traumatic brain injury: a prospective study. Brain 2007;130:1873-1883.PubMed CrossRef
  88.Kaiser PR, Valko PO, Werth E, et al. Modafinil ameliorates excessive daytime sleepiness after traumatic brain injury. Neurology 2010;75:1780-1785.PubMed CrossRef
  89.Menn SJ, Yang R, Lankford A. Armodafinil for the treatment of excessive sleepiness associated with mild or moderate closed traumatic brain injury: a 12-week, randomized, double-blind study followed by a 12-month open-label extension. J Clin Sleep Med 2014;10:1181-1191.PubMed PubMedCentral
  90.Ponsford JL, Ziino C, Parcell DL, et al. Fatigue and sleep disturbance following traumatic brain injury--their nature, causes, and potential treatments. J Head Trauma Rehabil 2012;27:224-233.PubMed CrossRef
  91.Wilde MC, Castriotta RJ, Lai JM, Atanasov S, Masel BE, Kuna ST. Cognitive impairment in patients with traumatic brain injury and obstructive sleep apnea. Arch Phys Med Rehabil 2007;88:1284-1288.PubMed CrossRef
  92.Wickwire EM, Lettieri CJ, Cairns AA, Collop NA. Maximizing positive airway pressure adherence in adults: a common-sense approach. Chest 2013;144:680-693.PubMed CrossRef
  93.Wickwire EM, Smith MT, Birnbaum S, Collop NA. Sleep maintenance insomnia complaints predict poor CPAP adherence: a clinical case series. Sleep Med 2010;11:772-776.PubMed CrossRef
  94.Collen JF, Lettieri CJ, Hoffman M. The impact of posttraumatic stress disorder on CPAP adherence in patients with obstructive sleep apnea. J Clin Sleep Med 2012;8:667-672.PubMed PubMedCentral
  95.Lettieri CJ, Williams SG, Collen JF. Obstructive sleep apnea syndrome and post-traumatic stress disorder: Clinical outcomes and impact of PAP therapy. Chest 2015 Aug 20 [Epub ahead of print].
  96.Clinchot DM, Bogner J, Mysiw WJ, Fugate L, Corrigan J. Defining sleep disturbance after brain injury. Am J Phys Med Rehabil 1998;77:291-295.PubMed CrossRef
  97.Ates O, Cayli S, Gurses I, et al. Effect of pinealectomy and melatonin replacement on morphological and biochemical recovery after traumatic brain injury. Int J Dev Neurosci 2006;24:357-363.PubMed CrossRef
  98.Colorado Division of Workers' Compensation. Traumatic brain injury medical treatment guidelines. 2012:1–119.
  99.Chiu HY, Lin EY, Wei L, et al. Hypnotics use but not insomnia increased the risk of dementia in traumatic brain injury patients. Eur Neuropsychopharmacol 2015;25:2271-2277.PubMed CrossRef
  100.Morin CM, Colecchi C, Stone J, Sood R, Brink D. Behavioral and pharmacological therapies for late-life insomnia: a randomized controlled trial. JAMA 1999;281:991-999.PubMed CrossRef
  101.Jacobs GD, Pace-Schott EF, Stickgold R, Otto MW. Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison. Arch Intern Med 2004;164:1888-1896.PubMed CrossRef
  102.Sivertsen B, Omvik S, Pallesen S, et al. Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA 2006;295:2851-2858.PubMed CrossRef
  103.Morin CM, Vallieres A, Guay B, et al. Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial. JAMA 2009;301:2005-2015.PubMed PubMedCentral CrossRef
  104.No authors listed. NIH. State of the science conference statement on manifestations and management of chronic insomnia in adults statement. J Clin Sleep Med 2005;1:412-421.
  105.Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med 2008;4:487-504.PubMed PubMedCentral
  106.De La Rue-Evans L, Nesbitt K, Oka RK. Sleep hygiene program implementation in patients with traumatic brain injury. Rehabil Nurs 2013;38:2-10.CrossRef
  107.Kemp S, Biswas R, Neumann V, Coughlan A. The value of melatonin for sleep disorders occurring post-head injury: a pilot RCT. Brain Inj 2004;18:911-919.PubMed CrossRef
  108.Barr T, Livingston W, Guardado P, Baxter T, Mysliwiec V, Gill J. Chapter 8 military personnel with traumatic brain injuries and insomnia have reductions in PTSD and improved perceived health following sleep restoration: a relationship moderated by inflammation. Annu Rev Nurs Res 2015;33:249-266.PubMed CrossRef
  109.Dean PJ, Sato JR, Vieira G, McNamara A, Sterr A. Long-term structural changes after mTBI and their relation to post-concussion symptoms. Brain Inj 2015 Jun 11 [Epub ahead of print].
  110.Valko PO, Gavrilov YV, Yamamoto M, et al. Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury. Ann Neurol 2015;77:177-182.PubMed CrossRef
  111.Baumann CR, Stocker R, Imhof HG, et al. Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury. Neurology 2005;65:147-149.PubMed CrossRef
  112.Rye DB, Bliwise DL, Parker K, et al. Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Sci Transl Med 2012;4:161ra151.PubMed CrossRef
  113.Becelewski J, Pierzchala K. Cerebrovascular reactivity in patients with mild head injury. Neurol Neurochir Pol 2003;37:339-350.PubMed
  114.Junger EC, Newell DW, Grant GA, et al. Cerebral autoregulation following minor head injury. J Neurosurg 1997;86:425-432.PubMed CrossRef
  115.Kumar A, Loane DJ. Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. Brain Behav Immun 2012;26:1191-1201.PubMed CrossRef
  116.Paparrigopoulos T, Melissaki A, Tsekou H, et al. Melatonin secretion after head injury: a pilot study. Brain Inj 2006;20:873-878.PubMed CrossRef
  117.Seifman MA, Gomes K, Nguyen PN, et al. Measurement of serum melatonin in intensive care unit patients: changes in traumatic brain injury, trauma, and medical conditions. Front Neurol 2014;5:237.PubMed PubMedCentral CrossRef
  118.Gilbert KS, Kark SM, Gehrman P, Bogdanova Y. Sleep disturbances, TBI and PTSD: Implications for treatment and recovery. Clin Psychol Rev 2015;40:195-212.PubMed CrossRef
  119.Lavigne G, Khoury S, Chauny JM, Desautels A. Pain and sleep in post-concussion/mild traumatic brain injury. Pain 2015;156(Suppl. 1):S75-S85.PubMed CrossRef
  120.Tan G, Fink B, Dao TK, et al. Associations among pain, PTSD, mTBI, and heart rate variability in veterans of Operation Enduring and Iraqi Freedom: a pilot study. Pain Med 2009;10:1237-1245.PubMed CrossRef
  121.Blaylock RL, Maroon J. Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy: a unifying hypothesis. Surg Neurol Int 2011;2:107.PubMed PubMedCentral CrossRef
  122.Lusardi TA, Lytle NK, Szybala C, Boison D. Caffeine prevents acute mortality after TBI in rats without increased morbidity. Exp Neurol 2012;234:161-168.PubMed PubMedCentral CrossRef
  123.Terrio H, Brenner LA, Ivins BJ, et al. Traumatic brain injury screening: preliminary findings in a US Army Brigade Combat Team. J Head Trauma Rehabil 2009;24:14-23.PubMed CrossRef
  124.Farrell-Carnahan L, Franke L, Graham C, McNamee S. Subjective sleep disturbance in veterans receiving care in the Veterans Affairs Polytrauma System following blast-related mild traumatic brain injury. Mil Med 2013;178:951-956.PubMed CrossRef
  125.Defense Veterans Brain Injury Center. TBI basics. Available at: http://​dvbic.​dcoe.​mil/​about-traumatic
  ain-injury/​article/​tbi-basics . Accessed October 1, 2015.
  126.Gerdes L, Gerdes P, Lee SW, H Tegeler C. HIRREM: a noninvasive, allostatic methodology for relaxation and auto-calibration of neural oscillations. Brain Behav 2013;3:193-205.PubMed PubMedCentral CrossRef
  127.Lee SW, Gerdes L, Tegeler CL, Shaltout HA, Tegeler CH. A bihemispheric autonomic model for traumatic stress effects on health and behavior. Front Psychol 2014;5:843.PubMed PubMedCentral
  128.Morries LD, Cassano P, Henderson TA. Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy. Neuropsychiatr Dis Treat 2015;11:2159-2175.PubMed PubMedCentral
  129.Lucke-Wold BP, Smith KE, Nguyen L, et al. Sleep disruption and the sequelae associated with traumatic brain injury. Neurosci Biobehav Rev 2015;55:68-77.PubMed PubMedCentral CrossRef
  130.Dikmen S, McLean A, Temkin N. Neuropsychological and psychosocial consequences of minor head injury. J Neurol Neurosurg Psychiatry 1986;49:1227-1232.PubMed PubMedCentral CrossRef
  131.Suh S, Nowakowski S, Bernert RA, et al. Clinical significance of night-to-night sleep variability in insomnia. Sleep Med 2012;13:469-475.PubMed PubMedCentral CrossRef
  132.Okun ML, Reynolds CF, 3rd, Buysse DJ, et al. Sleep variability, health-related practices, and inflammatory markers in a community dwelling sample of older adults. Psychosom Med 2011;73:142-150.PubMed PubMedCentral CrossRef
  133.Buysse DJ, Cheng Y, Germain A, et al. Night-to-night sleep variability in older adults with and without chronic insomnia. Sleep Med 2010;11:56-64.PubMed PubMedCentral CrossRef
  134.Sanchez-Ortuno MM, Edinger JD. Internight sleep variability: its clinical significance and responsiveness to treatment in primary and comorbid insomnia. J Sleep Res 2012;21:527-534.PubMed CrossRef
  135.Shiffman S, Stone AA, Hufford MR. Ecological momentary assessment. Annu Rev Clin Psychol 2008;4:1-32.PubMed CrossRef
  136.Polinder S, Haagsma JA, van Klaveren D, Steyerberg EW, van Beeck EF. Health-related quality of life after TBI: a systematic review of study design, instruments, measurement properties, and outcome. Popul Health Metr 2015;13:4.PubMed PubMedCentral CrossRef
  137.Wickwire EM, Shaya FT, Scharf SM. Health economics of insomnia treatments: The return on investment for a good night’s sleep. Sleep Medicine Reviews 30(2016):72-82.
  
• 作者单位：Emerson M. Wickwire (1) (2)
  Scott G. Williams (3) (4)
  Thomas Roth (5)
  Vincent F. Capaldi (6)
  Michael Jaffe (7) (8) (9)
  Margaret Moline (10)
  Gholam K. Motamedi (11)
  Gregory W. Morgan (12)
  Vincent Mysliwiec (13) (4)
  Anne Germain (14)
  Renee M. Pazdan (15)
  Reuven Ferziger (16)
  Thomas J. Balkin (6)
  Margaret E. MacDonald (17)
  Thomas A. Macek (18)
  Michael R. Yochelson (19) (20)
  Steven M. Scharf (2)
  Christopher J. Lettieri (4)
  
  1. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
  2. Sleep Disorders Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
  3. Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, USA
  4. Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
  5. Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USA
  6. Department of Behavioral Biology, Walter Reed Army Institute of Research, Center for Military Psychiatry and Neuroscience Research, Silver Spring, MD, USA
  7. Department of Neurology, University of Florida, Gainesville, FL, USA
  8. Concussion and Sports Program, University of Florida Trauma, Gainesville, FL, USA
  9. UF Health Sleep Disorders Center, Gainesville, FL, USA
  10. Eisai, Inc., Woodcliff Lake, NJ, USA
  11. Department of Neurology, Georgetown University Hospital, Washington, DC, USA
  12. Sleep Disorders Center, National Intrepid Center of Excellence, Bethesda, MD, USA
  13. Department of Sleep Medicine, San Antonio Military Medical Center, San Antonio, TX, USA
  14. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
  15. U.S. Public Health Service, Fort Carson, CO, USA
  16. Merck and Co, Kenilworth, NJ, USA
  17. Defense and Veterans Brain Injury Center, (Contractor, General Dynamics Health Solutions), Evans Army Community Hospital, Fort Carson, CO, USA
  18. Department of Clinical Science, CNS, Takeda Development Center – Americas, Deerfield, IL, USA
  19. Medstar National Rehabilitation Network, Washington, DC, USA
  20. Departments of Neurology and Rehabilitation Medicine, Georgetown University School of Medicine, Washington, DC, USA
  
• 刊物主题：Neurosciences; Neurology; Neurosurgery; Neurobiology;
• 出版者：Springer US
• ISSN：1878-7479

文摘

Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.