Echinomycin did not affect the safety of fracture healing: an experimental pilot study on a murine femur fracture model

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• 作者：Thorsten Jentzsch ; Stefan M. Zimmermann ; Flora Nicholls…
• 关键词：Heterotopic ossification (HO) ; Echinomycin ; Bone healing ; Callus formation ; Murine femur fracture model
• 刊名：Patient Safety in Surgery
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：10
• 期：1
• 全文大小：734 KB
• 刊物主题：Surgery;
• 出版者：BioMed Central
• ISSN：1754-9493

文摘

Background There is a need for effective drugs in the prevention and treatment of heterotopic ossifications (HO) after fractures. Echinomycin has been shown to prevent formation of HO in an animal model. However, before it may be considered as an option against HO, it needs to be studied whether it prevents fracture healing similar to non-steroidal anti-inflammatory drugs (NSAIDS). Therefore, the hypothesis was that echinomycin prevents fracture healing and callus formation.