Effect of topographical control by a micro-molding process on the activity of human Mesenchymal Stem Cells on alumina ceramics

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• 作者：Soo-Yean Kim ; Jong-Ho Kang ; Won-Seon Seo ; Suk-Won Lee ; Nam-Sik Oh…
• 关键词：Microgroove ; Alumina ; Human Mesenchymal Stem Cell ; Micro ; molding ; Polydimethylsiloxane
• 刊名：Biomaterials Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：19
• 期：1
• 全文大小：1,894 KB
• 刊物类别：Biomaterials;
• 刊物主题：Biomaterials;
• 出版者：BioMed Central
• ISSN：2055-7124

文摘

Background Numerous studies have reported that microgrooves on metal and polymer materials can affect cell adhesion, proliferation, differentiation and guidance. However, our knowledge of the cell activity associated with microgrooves on ceramics, such as alumina, zirconia, hydroxyapatite and etc, is very incomplete, owing to difficulties in the engraving of microgrooves on the hard surface of the base material. In this study, microgrooves on alumina were fabricated by a casting process using a polydimethylsiloxane micro-mold. The cell responses of Human Mesenchymal Stem Cells on the alumina microgrooves were then evaluated.