miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151

详细信息    查看全文

• 作者：Ronglin Zhai (1)
  Xuefeng Kan (2)
  Bo Wang (1)
  Hansong Du (1)
  Yueping Long (1)
  Heshui Wu (1)
  Kaixiong Tao (1)
  Guobin Wang (1)
  Lihong Bao (3)
  Fen Li (3)
  Wanli Zhang (3)
  
• 关键词：miR ; 152 ; CD151 ; Gastric cancer ; Growth ; Metastasis
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：35
• 期：11
• 页码：11367-11373
• 全文大小：1,122 KB
• 参考文献：1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69鈥?0. CrossRef
  2. Wang YY, Ye ZY, Zhao ZS, Tao HQ, Li SG. Systems biology approach to identification of biomarkers for metastatic progression in gastric cancer. J Cancer Res Clin Oncol. 2010;136:135鈥?1. CrossRef
  3. Otani K, Li X, Arakawa T, Chan FK, Yu J. Epigenetic-mediated tumor suppressor genes as diagnostic or prognostic biomarkers in gastric cancer. Expert Rev Mol Diagn. 2013;13:445鈥?5. CrossRef
  4. Zoller M. Gastrointestinal tumors: metastasis and tetraspanins. Z Gastroenterol. 2006;44:573鈥?6. CrossRef
  5. Pols MS, Klumperman J. Trafficking and function of the tetraspanin cd63. Exp Cell Res. 2009;315:1584鈥?2. CrossRef
  6. Sadej R, Romanska H, Kavanagh D, Baldwin G, Takahashi T, Kalia N, et al. Tetraspanin cd151 regulates transforming growth factor beta signaling: implication in tumor metastasis. Cancer Res. 2010;70:6059鈥?0. CrossRef
  7. Kwon MJ, Seo J, Kim YJ, Choi JY, Kim TE, Lee DH, et al. Prognostic significance of cd151 overexpression in non-small cell lung cancer. Lung Cancer. 2013;81:109鈥?6. CrossRef
  8. Yang YM, Zhang ZW, Liu QM, Sun YF, Yu JR, Xu WX. Overexpression of cd151 predicts prognosis in patients with resected gastric cancer. PLoS One. 2013;8:e58990. CrossRef
  9. Zhang N, Wei X, Xu L. Mir-150 promotes the proliferation of lung cancer cells by targeting p53. FEBS Lett. 2013;587:2346. CrossRef
  10. Ayaz L, Gorur A, Yaroglu HY, Ozcan C, Tamer L. Differential expression of micrornas in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma. J Cancer Res Clin Oncol. 2013;139:1499. CrossRef
  11. Wach S, Nolte E, Theil A, Stohr C, Rau TT, Hartmann A, et al. Microrna profiles classify papillary renal cell carcinoma subtypes. Br J Cancer. 2013;109:714. CrossRef
  12. Chen J, Yao D, Li Y, Chen H, He C, Ding N, et al. Serum microrna expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. Int J Mol Med. 2013;32:557.
  13. Chang L, Guo F, Wang Y, Lv Y, Huo B, Wang L, et al. Microrna-200c regulates the sensitivity of chemotherapy of gastric cancer sgc7901/ddp cells by directly targeting rhoe. Pathol Oncol Res. 2013;20:93. CrossRef
  14. Jiang B, Li Z, Zhang W, Wang H, Zhi X, Feng J, et al. Mir-874 inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer. J Gastroenterol. 2013;49:1011. CrossRef
  15. Chen Y, Song Y, Wang Z, Yue Z, Xu H, Xing C, et al. Altered expression of mir-148a and mir-152 in gastrointestinal cancers and its clinical significance. J Gastrointest Surg. 2010;14:1170鈥?. CrossRef
  16. Huang J, Wang Y, Guo Y, Sun S. Down-regulated microrna-152 induces aberrant DNA methylation in hepatitis b virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology. 2010;52:60鈥?0. CrossRef
  17. Zhu C, Li J, Ding Q, Cheng G, Zhou H, Tao L, et al. Mir-152 controls migration and invasive potential by targeting TGFalpha in prostate cancer cell lines. Prostate. 2013;73:1082鈥?. CrossRef
  18. Xiang Y, Ma N, Wang D, Zhang Y, Zhou J, Wu G, et al. Mir-152 and mir-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting dnmt1 directly: a novel epigenetic therapy independent of decitabine. Oncogene. 2013;33:378. CrossRef
  19. Hemler ME. Tetraspanin functions and associated microdomains. Nat Rev Mol Cell Biol. 2005;6:801鈥?1. CrossRef
  20. Han ZB, Yang Z, Chi Y, Zhang L, Wang Y, Ji Y, et al. Microrna-124 suppresses breast cancer cell growth and motility by targeting cd151. Cell Physiol Biochem. 2013;31:823鈥?2. CrossRef
  21. Fei Y, Wang J, Liu W, Zuo H, Qin J, Wang D, et al. Cd151 promotes cancer cell metastasis via integrins alpha3beta1 and alpha6beta1 in vitro. Mol Med Rep. 2012;6:1226鈥?0.
  22. Rubinstein E. The complexity of tetraspanins. Biochem Soc Trans. 2011;39:501鈥?. CrossRef
  
• 作者单位：Ronglin Zhai (1)
  Xuefeng Kan (2)
  Bo Wang (1)
  Hansong Du (1)
  Yueping Long (1)
  Heshui Wu (1)
  Kaixiong Tao (1)
  Guobin Wang (1)
  Lihong Bao (3)
  Fen Li (3)
  Wanli Zhang (3)
  
  1. Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
  2. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
  3. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
  
• ISSN：1423-0380

文摘

We aimed to study the post-translational regulation of CD151 by the microRNA miR-152. CD151 is highly expressed in gastric cancer (GC) and has been shown to accelerate GC by enhancing invasion and metastasis; however, its regulation is still unclear. Our results showed decreased expression of miR-152 in GC tissue samples and cell lines. In addition, miR-152 complementation significantly inhibits both the proliferation and motility of GC cells. CD151 was found to be a target of miR-152, and overexpression of CD151 attenuated the suppressive effect of miR-152. Our findings highlight an essential role of miR-152 in the regulation of proliferation and motility of GC cells and suggest a potential application of miR-152 in GC treatment.