Factors influencing the incidence of sinusitis in nasopharyngeal carcinoma patients after intensity-modulated radiation therapy

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• 作者：Yan-xia Su (1) (2)
  Lan-ping Liu (1)
  Lei Li (3)
  Xu Li (4)
  Xiu-juan Cao (1)
  Wei Dong (1)
  Xin-hua Yang (1)
  Jin Xu (1)
  Shui Yu (1)
  Jun-fang Hao (1)
  
• 关键词：Sinusitis ; Nasopharyngeal carcinoma ; Intensity ; modulated radiotherapy
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：271
• 期：12
• 页码：3195-3201
• 全文大小：271 KB
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• 作者单位：Yan-xia Su (1) (2)
  Lan-ping Liu (1)
  Lei Li (3)
  Xu Li (4)
  Xiu-juan Cao (1)
  Wei Dong (1)
  Xin-hua Yang (1)
  Jin Xu (1)
  Shui Yu (1)
  Jun-fang Hao (1)
  
  1. The Ninth Clinical Department of Radiation Oncology, Shandong Tumor Hospital, 440 Jiyan Road, Jinan, 250117, People’s Republic of China
  2. School of Medicine and Life Sciences, University of Jinan-Shandong Academey of Medical Sciences, Jinan, People’s Republic of China
  3. The Department of PET-CT Center, Shandong Tumor Hospital, Jinan, People’s Republic of China
  4. The Department of Radiation Oncology, Shandong Tumor Hospital, Jinan, People’s Republic of China
  
• ISSN：1434-4726

文摘

The aim of the study was to investigate the incidence of sinusitis in nasopharyngeal carcinoma (NPC) patients before and after intensity-modulated radiation therapy (IMRT) and to analyze factors associated with the incidence of sinusitis following IMRT. We retrospectively analyzed 283 NPC patients who received IMRT in our hospital from March 2009 to May 2011. The diagnostic criteria for sinusitis are based on computed tomography (CT) or magnetic resonance imaging (MRI) findings. CT or MRI scans were performed before and after IMRT to evaluate the incidence of sinusitis. Factors influencing the incidence of sinusitis were analyzed by log-rank univariate and logistic multivariate analyses. Among the 283 NPC patients, 128 (45.2?%) suffered from sinusitis before radiotherapy. The incidence rates of sinusitis in patients with T1, T2, T3, and T4 NPC before radiotherapy were 22.6, 37.5, 46.8, and 61.3?%, respectively (χ 2?=?14.548, p?=?0.002). Among the 155 NPC patients without sinusitis before radiotherapy, the incidence rates of sinusitis at the end of radiotherapy and at 1, 3, 6, 9, 12, and 18?months after radiotherapy were 32.9, 43.2, 61.3, 68.4, 73.5, 69.7, and 61.3?%, respectively (χ 2?=?86.461, p?IMRT (p?=?0.003, 0.006, 0.002, and 0.020). Multivariate analysis showed that T stage, invasion of the nasal cavity, and nasal irrigation were influential factors for the incidence of sinusitis in NPC patients after IMRT (p?=?0.002, 0.002, and 0.000). There was a higher incidence of sinusitis with higher T stage among NPC patients before radiotherapy, and the incidence of sinusitis in NPC patients after IMRT was high (45.2?%). The incidence of sinusitis increased rapidly within the first 3?months after IMRT, and the number of sinusitis cases peaked at 6-?months after IMRT and showed a trend toward stabilization after 1?year. Advanced T stage, invasion of the nasal cavity, and nasal irrigation were positively associated with the incidence of sinusitis in NPC patients after IMRT.