用户名： 密码： 验证码：
CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models
详细信息    查看全文
  • 作者：Sun-Hee Kim (1)
    Ofer Margalit (2)
    Hiroshi Katoh (2)
    Dingzhi Wang (2)
    Hong Wu (1)
    Dianren Xia (1)
    Vijaykumar R. Holla (1)
    Peiying Yang (3)
    Raymond N. DuBois (2) (4)
  • 关键词：Colorectal cancer ; COX ; 2 ; CG100649 ; Celecoxib ; PGE2 ; Carbonic anhydrase ; I/ ; II
  • 刊名：Investigational New Drugs
  • 出版年：2014
  • 出版时间：December 2014
  • 年：2014
  • 卷：32
  • 期：6
  • 页码：1105-1112
  • 全文大小：1,139 KB
  • 参考文献：1. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646鈥?74. doi:10.1016/j.cell.2011.02.013 CrossRef
    2. Wang D, Dubois RN (2012) The role of anti-inflammatory drugs in colorectal cancer. Annu Rev Med. doi:10.1146/annurev-med-112211-154330
    3. Arber N, Eagle CJ, Spicak J, Racz I, Dite P, Hajer J, Zavoral M, Lechuga MJ, Gerletti P, Tang J, Rosenstein RB, Macdonald K, Bhadra P, Fowler R, Wittes J, Zauber AG, Solomon SD, Levin B (2006) Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med 355(9):885鈥?95. doi:10.1056/NEJMoa061652 CrossRef
    4. Baron JA, Sandler RS, Bresalier RS, Quan H, Riddell R, Lanas A, Bolognese JA, Oxenius B, Horgan K, Loftus S, Morton DG (2006) A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. Gastroenterology 131(6):1674鈥?682. doi:10.1053/j.gastro.2006.08.079 CrossRef
    5. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim K, Tang J, Rosenstein RB, Wittes J, Corle D, Hess TM, Woloj GM, Boisserie F, Anderson WF, Viner JL, Bagheri D, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Gordon GB, Hawk ET (2006) Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med 355(9):873鈥?84. doi:10.1056/NEJMoa061355 CrossRef
    6. Chan AT, Ogino S, Fuchs CS (2009) Aspirin use and survival after diagnosis of colorectal cancer. Jama 302(6):649鈥?58. doi:10.1001/jama.2009.1112 CrossRef
    7. Chan AT, Ogino S, Fuchs CS (2007) Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med 356(21):2131鈥?142. doi:10.1056/NEJMoa067208 CrossRef
    8. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107(4):1183鈥?188
    9. Wang D, Dubois RN (2010) Eicosanoids and cancer. Nat Rev Cancer 10(3):181鈥?93. doi:10.1038/nrc2809 CrossRef
    10. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, Lines C, Riddell R, Morton D, Lanas A, Konstam MA, Baron JA (2005) Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 352(11):1092鈥?102. doi:10.1056/NEJMoa050493 CrossRef
    11. Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, Anderson WF, Zauber A, Hawk E, Bertagnolli M (2005) Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med 352(11):1071鈥?080. doi:10.1056/NEJMoa050405 CrossRef
    12. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Breazna A, Kim K, Tang J, Rosenstein RB, Umar A, Bagheri D, Collins NT, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Hawk ET (2009) Five-year efficacy and safety analysis of the adenoma prevention with celecoxib trial. Cancer Prev Res (Phila) 2(4):310鈥?21. doi:10.1158/1940-6207.CAPR-08-0206 CrossRef
    13. McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA (1999) Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A 96(1):272鈥?77 CrossRef
    14. Grosser T, Yu Y, Fitzgerald GA (2010) Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annu Rev Med 61:17鈥?3. doi:10.1146/annurev-med-011209-153129 CrossRef
    15. Yu Y, Ricciotti E, Grosser T, Fitzgerald GA (2009) The translational therapeutics of prostaglandin inhibition in atherothrombosis. J Thromb Haemost 7(Suppl 1):222鈥?26. doi:10.1111/j.1538-7836.2009.03439.x CrossRef
    16. Coxib, traditional NTC, Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J, Baigent C (2013) Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet 382(9894):769鈥?79. doi:10.1016/S0140-6736(13)60900-9 CrossRef
    17. Aw TJ, Haas SJ, Liew D, Krum H (2005) Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. Arch Intern Med 165(5):490鈥?96. doi:10.1001/archinte.165.5.IOI50013 CrossRef
    18. Skarke C, Alamuddin N, Lawson JA, Cen L, Propert KJ, Fitzgerald GA (2012) Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther 91(6):986鈥?93. doi:10.1038/clpt.2012.3 CrossRef
    19. Yang P, Felix E, Madden T, Fischer SM, Newman RA (2002) Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells. Anal Biochem 308(1):168鈥?77 CrossRef
    20. Shao J, Sheng H, Inoue H, Morrow JD, DuBois RN (2000) Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. J Biol Chem 275(43):33951鈥?3956. doi:10.1074/jbc.M002324200 CrossRef
    21. Sharma RA, Gescher A, Plastaras JP, Leuratti C, Singh R, Gallacher-Horley B, Offord E, Marnett LJ, Steward WP, Plummer SM (2001) Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells. Carcinogenesis 22(9):1557鈥?560 CrossRef
    22. Moser AR, Pitot HC, Dove WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247(4940):322鈥?24 CrossRef
    23. Chan AT, Sima CS, Zauber AG, Ridker PM, Hawk ET, Bertagnolli MM (2011) C-reactive protein and risk of colorectal adenoma according to celecoxib treatment. Cancer Prev Res (Phila) 4(8):1172鈥?180. doi:10.1158/1940-6207.CAPR-10-0403 CrossRef
    24. Xia D, Wang D, Kim SH, Katoh H, DuBois RN (2012) Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat Med 18(2):224鈥?26. doi:10.1038/nm.2608 CrossRef
    25. Kargman SL, O鈥橬eill GP, Vickers PJ, Evans JF, Mancini JA, Jothy S (1995) Expression of prostaglandin G/H synthase-1 and 鈭? protein in human colon cancer. Cancer Res 55(12):2556鈥?559
    26. Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M, Hla T (1995) Expression of cyclooxygenase-1 and 鈭? in human colorectal cancer. Cancer Res 55(17):3785鈥?789
    27. Chapple KS, Cartwright EJ, Hawcroft G, Tisbury A, Bonifer C, Scott N, Windsor AC, Guillou PJ, Markham AF, Coletta PL, Hull MA (2000) Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. Am J Pathol 156(2):545鈥?53. doi:10.1016/S0002-9440(10)64759-1 CrossRef
    28. van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111(2):241鈥?50 CrossRef
  • 作者单位：Sun-Hee Kim (1)
    Ofer Margalit (2)
    Hiroshi Katoh (2)
    Dingzhi Wang (2)
    Hong Wu (1)
    Dianren Xia (1)
    Vijaykumar R. Holla (1)
    Peiying Yang (3)
    Raymond N. DuBois (2) (4)

    1. Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    2. Laboratory for Inflammation and Cancer, Arizona State University Biodesign Institute, Tempe, AZ, USA
    3. Departments of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    4. Department of Research and Division of Gastroenterology, Mayo Clinic, Scottsdale, AZ, USA
  • ISSN：1573-0646
文摘

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址：北京市海淀区学院路29号 邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700