Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes

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• 作者：Bernardina T. Fokkens ; Andries J. Smit
• 刊名：Glycoconjugate Journal
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：33
• 期：4
• 页码：527-535
• 全文大小：343 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-4986
• 卷排序：33

文摘

Glycation is important in the development of complications of diabetes mellitus and may have a central role in the well-described glycaemic memory effect in developing these complications. Skin fluorescence has emerged over the last decade as a non-invasive method for assessing accumulation of advanced glycation endproducts. Skin fluorescence is independently related to micro- and macrovascular complications in both type 1 and type 2 diabetes mellitus and is associated with mortality in type 2 diabetes. The relation between skin fluorescence and cardiovascular disease also extends to other conditions with increased tissue AGE levels, such as renal failure. Besides cardiovascular complications, skin fluorescence has been associated, more recently, with other prevalent conditions in diabetes, such as brain atrophy and depression. Furthermore, skin fluorescence is related to past long-term glycaemic control and clinical markers of cardiovascular disease. This review will discuss the technique of skin fluorescence, its validation as a marker of tissue AGE accumulation, and its use as a clinical tool for the prediction of long-term complications in diabetes mellitus.KeywordsSkin autofluorescenceSkin intrinsic fluorescenceAdvanced glycation endproductsDiabetes mellitusDiabetes complications