Glycaemic Effects of Non-statin Lipid-Lowering Therapies

详细信息    查看全文

• 作者：Patrick D. Collins ; Naveed Sattar
• 关键词：Statins ; Hypercholesterolaemia ; PCSK9 ; Ezetimibe ; Niacin ; Diabetes
• 刊名：Current Cardiology Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：12
• 全文大小：261 KB
• 刊物主题：Cardiology;
• 出版者：Springer US
• ISSN：1534-3170
• 卷排序：18

文摘

Since the publication of the JUPITER trial, attention has been focused on the adverse glycemic effects of statin therapy. Although the modest increase in the risk of new diabetes mellitus is outweighed by the reduction in cardiovascular events for statins, emerging biochemical and genetic links between lipid metabolism and glycemic control raise the prospect of a broader diabetogenic effect of lipid-lowering therapies. For the novel and powerful PCSK9-inhibitor class available evidence does not support a major glycaemic effect with the results of large scale trials awaited although preliminary genetic data does suggest a link. In contrast, there is clear evidence of a diabetogenic effect for the now outdated but well-studied niacin. For ezetimibe and fibrates, evidence is scarce but currently broadly unconcerning. For now, the glycemic effects of lipid-lowering therapies should have a limited influence on clinical decision-making. Further study in this topical area is needed.