Regulation of lipid metabolism via a connection between the endoplasmic reticulum and lipid droplets

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• 作者：Michitaka Suzuki
• 关键词：Lipid droplets ; Endoplasmic reticulum ; Organelle interaction ; Lipid metabolism ; Protein degradation
• 刊名：Anatomical Science International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：92
• 期：1
• 页码：50-54
• 全文大小：
• 刊物主题：Anatomy; Human Physiology; Neurosciences; Cell Biology; Animal Anatomy / Morphology / Histology; Animal Physiology;
• 出版者：Springer Japan
• ISSN：1447-073X
• 卷排序：92

文摘

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids to regulate cellular lipid homeostasis. Fatty acids are packaged as triglyceride and cholesterol ester into endoplasmic reticulum (ER) membranes to synthesize LDs. Cytosolic LDs move dynamically and interact with organelles, including other LDs. In this process, functional proteins for metabolism are also transferred to LDs. In this review, I focus on interactions between the ER and LDs related to lipid metabolism.