Th17 and CD24^hiCD27⁺ regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritis

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• 作者：Sarah Salomon ; Caroline Guignant ; Pierre Morel…
• 关键词：Rheumatoid arthritis ; Biomarker ; Lymphocyte ; Th17 ; Breg ; Treg ; Response ; Remission ; Abatacept ; Anti ; TNF
• 刊名：Arthritis Research & Therapy
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：744KB
• 刊物主题：Rheumatology; Orthopedics;
• 出版者：BioMed Central
• ISSN：1478-6362
• 卷排序：19

文摘

BackgroundThe aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomarkers of response in rheumatoid arthritis (RA).