Effects of manganese on potassium outflow from erythrocytes and on respiration of rat liver mitochondria

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• 作者：M. S. Goncharenko ; A. I. Tkachenko…
• 关键词：manganese chloride ; potassium ; erythrocytes ; rat liver mitochondria ; respiration
• 刊名：Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：11
• 期：1
• 页码：77-81
• 全文大小：
• 刊物主题：Cell Biology;
• 出版者：Pleiades Publishing
• ISSN：1990-7494
• 卷排序：11

文摘

In this work, effects of manganese on respiration of rat liver mitochondria and the rate of K+ outflow from rat erythrocytes are studied in a broad range of concentrations. It is shown that manganese ions at low concentrations (1 × 10–7–3 × 10–5 М) inhibit K+ outflow from rat erythrocytes; this can be used to prevent their lysis. At high concentrations (1 × 10–4–1 × 10–3 M), manganese activates K+ outflow from the erythrocytes but inhibits the valinomycin-induced outflow of the ion from the erythrocytes. This fact is an indication of manganese influence on physicochemical properties of membranes. At low concentrations manganese does not affect parameters of respiration and oxidative phosphorylation of rat liver mitochondria, while at high concentrations it exerts acceleration of the mitochondrial respiration, i.e., uncouples respiration from phosphorilation and, hence, inhibits ATP synthesis.