Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer

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• 作者：M. Ampuja ; T. Rantapero ; A. Rodriguez-Martinez ; M. Palmroth ; E. L. Alarmo…
• 关键词：Bone morphogenetic protein ; Breast cancer ; NGS ; RNA ; seq ; DNase ; seq ; Transcription factor
• 刊名：BMC Genomics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1484KB
• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164
• 卷排序：18

文摘

BackgroundBone morphogenetic protein 4 (BMP4) plays an important role in cancer pathogenesis. In breast cancer, it reduces proliferation and increases migration in a cell line-dependent manner. To characterize the transcriptional mediators of these phenotypes, we performed RNA-seq and DNase-seq analyses after BMP4 treatment in MDA-MB-231 and T-47D breast cancer cells that respond to BMP4 with enhanced migration and decreased cell growth, respectively.