Urinary sediment miRNAs reflect tubulointerstitial damage and therapeutic response in IgA nephropathy

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• 作者：Shuang Liang ; Guang-Yan Cai ; Zhi-Yu Duan ; Shu-wen Liu ; Jie Wu ; Yang Lv…
• 关键词：IgA nephropathy ; Urinary sediment ; miRNAs ; Tubulointerstitial damage ; Therapeutic response
• 刊名：BMC Nephrology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：708KB
• 刊物主题：Nephrology; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2369
• 卷排序：18

文摘

BackgroundImmunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. The clinical spectrum of IgAN varies from minor urinary abnormalities to rapidly progressive renal failure. Evaluation of the disease by repeated renal biopsy is not practical due to its invasive procedure. Urinary sediment miRNAs promise to serve as non-invasive biomarkers to assess kidney injury of IgAN.