Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells

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• 作者：Yan-Mei Ma ; Gordon Ibeanu ; Li-Yao Wang ; Jian-Zhong Zhang ; Yue Chang…
• 关键词：Glutamate toxicity ; Autophagy ; Mitochondrial fission ; Selenium
• 刊名：BMC Neuroscience
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：2771KB
• 刊物主题：Neurosciences; Neurobiology; Animal Models;
• 出版者：BioMed Central
• ISSN：1471-2202
• 卷排序：18

文摘

BackgroundPrevious studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic feature. However, the exact mechanisms by which selenium protects against glutamate-provoked mitochondrial perturbation remain ambiguous. In this study glutamate exposed murine hippocampal neuronal HT22 cell was used as a model to investigate the underlying mechanisms of selenium-dependent protection against mitochondria damage.