Up-regulation of CRKL by microRNA-335 methylation is associated with poor prognosis in gastric cancer

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• 作者：Jia-kui Zhang ; Yong-shuang Li ; Chun-dong Zhang ; Dong-qiu Dai
• 关键词：Gastric cancer ; MicroRNA ; MiR ; 335 ; Methylation ; Prognosis
• 刊名：Cancer Cell International
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：3152KB
• 刊物主题：Cancer Research; Cell Biology;
• 出版者：BioMed Central
• ISSN：1475-2867
• 卷排序：17

文摘

BackgroundMicroRNAs have been suggested to play a vital role in regulating carcinogenesis, tumor progression and invasion. MiR-335 is involved in suppressing metastasis and invasion in various human cancers. However, the mechanisms responsible for the aberrant expression of miR-335 in gastric cancer (GC) remain unknown.