Discovery, Genomic Analysis, and Functional Role of the Erythrocyte RNAs

详细信息    查看全文

• 作者：Po-Han Chen ; Jonathan Hong ; Jen-Tsan Chi
• 关键词：Erythrocyte ; microRNA ; transcriptome ; sickle cell disease ; malaria
• 刊名：Current Pathobiology Reports
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：5
• 期：1
• 页码：43-48
• 全文大小：
• 刊物主题：Pathology;
• 出版者：Springer US
• ISSN：2167-485X
• 卷排序：5

文摘

Purpose of ReviewHuman erythrocytes are responsible for oxygen delivery in the body. Erythrocytes are a product of terminal differentiated erythroid cells that accumulate hemoglobin and exclude nuclei. The long-held conventional wisdom has been that mature erythrocytes lack any genetic materials. Contrary to this view, accumulating evidence from multiple groups indicates that erythrocytes contain abundant and diverse RNA species. These newly discovered genetic materials suddenly open up opportunities to re-examine many diseases affecting erythrocytes.