Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

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• 作者：Kely Campos Navegantes ; Rafaelli de Souza Gomes…
• 关键词：Macrophages ; Neutrophils ; Autoimmunity ; Autoimmune disease ; Inflammation
• 刊名：Journal of Translational Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：2081KB
• 刊物主题：Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876
• 卷排序：15

文摘

Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, and especially certain autoimmune disease. However, little is known regarding the contribution of these cells to the pathogenesis of autoimmune disorders. Recent studies have aimed to clarify certain important factors affecting the immunogenicity of these cells, including the type and dose of antigen, the microenvironment of the cell-antigen encounter, and the number, subset, and phenotype of these cells, which can prevent or induce autoimmune responses. This review highlights the role of macrophage subsets and neutrophils in injured tissues, supporting their cooperation during the pathogenesis of certain autoimmune diseases.