Genetic diversity of Plasmodium vivax metacaspase 1 and Plasmodium vivax multi-drug resistance 1 genes of field isolates from Mauritania, Sudan and Oman

详细信息    查看全文

• 作者：Fatimata Sow ; Guillaume Bonnot ; Bilal Rabah Ahmed ; Sidi Mohamed Diagana…
• 关键词：Plasmodium vivax ; Metacaspases ; PvMCA1 ; cd ; pvmdr1 gene ; SNP ; Drug resistance ; Apoptose ; Oman ; Mauritania ; Sudan
• 刊名：Malaria Journal
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：1098KB
• 刊物主题：Parasitology; Tropical Medicine; Infectious Diseases; Entomology; Microbiology; Public Health;
• 出版者：BioMed Central
• ISSN：1475-2875
• 卷排序：16

文摘

BackgroundPlasmodium vivax is the second most important human malaria parasite, widely spread across the world. This parasite is associated with important issues in the process toward malaria elimination, including potential for relapse and increased resistance to chloroquine. Plasmodium vivax multi-drug resistant (pvmdr1) is suspected to be a marker of resistance although definitive evidence is lacking. Progress has been made in knowledge of biological factors affecting parasite growth, including mechanisms of regulated cell death and the suspected role of metacaspase. Plasmodium vivax metacaspase1 (PvMCA1-cd) has been described with a catalytic domain composed of histidine (H372) and cysteine (C428) residues. The aim of this study was to test for a link between the conserved histidine and cysteine residues in PvMCA1-cd, and the polymorphism of the P. vivax multi-drug resistant gene (pvmdr1).