Tick-borne pathogens induce differential expression of genes promoting cell survival and host resistance in Ixodes ricinus cells

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• 作者：Karen L. Mansfield ; Charlotte Cook ; Richard J. Ellis…
• 关键词：Tick cell ; Flavivirus ; Anaplasma phagocytophilum ; Ixodes ricinus ; Apoptosis ; Toll ; Transcriptomics ; Immunology
• 刊名：Parasites & Vectors
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：1191KB
• 刊物主题：Parasitology; Entomology; Tropical Medicine; Infectious Diseases; Veterinary Medicine/Veterinary Science; Virology;
• 出版者：BioMed Central
• ISSN：1756-3305
• 卷排序：10

文摘

BackgroundThere has been an emergence and expansion of tick-borne diseases in Europe, Asia and North America in recent years, including Lyme disease, tick-borne encephalitis and human anaplasmosis. The primary vectors implicated are hard ticks of the genus Ixodes. Although much is known about the host response to these bacterial and viral pathogens, there is limited knowledge of the cellular responses to infection within the tick vector. The bacterium Anaplasma phagocytophilum is able to bypass apoptotic processes in ticks, enabling infection to proceed. However, the tick cellular responses to infection with the flaviviruses tick-borne encephalitis virus (TBEV) and louping ill virus (LIV), which cause tick-borne encephalitis and louping ill respectively, are less clear.