RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells

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• 作者：Jeffrey M. Grabowski ; Monika Gulia-Nuss ; Richard J. Kuhn…
• 关键词：Ixodes scapularis ; Tick ; borne disease ; Flavivirus ; Langat ; ISE6 ; RNAi ; Functional studies ; Metabolism ; Protein ; processing
• 刊名：Parasites & Vectors
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：1256KB
• 刊物主题：Parasitology; Entomology; Tropical Medicine; Infectious Diseases; Veterinary Medicine/Veterinary Science; Virology;
• 出版者：BioMed Central
• ISSN：1756-3305
• 卷排序：10

文摘

BackgroundTick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection.