The predictive value of ¹⁸F-FDG PET-CT for assessing the clinical outcomes in locally advanced NSCLC patients after a new induction treatment: low-dose fractionated radiotherapy with concurrent chemotherapy

详细信息    查看全文

• 作者：Maria Vittoria Mattoli ; Mariangela Massaccesi…
• 关键词：18F ; FDG PET ; CT ; NSCLC ; Chemo ; radiotherapy ; PERCIST ; Tumour response
• 刊名：Radiation Oncology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：938KB
• 刊物主题：Cancer Research; Oncology; Radiotherapy; Imaging / Radiology;
• 出版者：BioMed Central
• ISSN：1748-717X
• 卷排序：12

文摘

BackgroundPatients with locally advanced non-small-cell lung cancer (LA-NSCLC) have poor prognosis despite several multimodal approaches. Recently, low-dose fractionated radiotherapy concurrent to the induction chemotherapy (IC-LDRT) has been proposed to further improve the effects of chemotherapy and prognosis. Until now, the predictive value of metabolic response after IC-LDRT has not yet been investigated. Aim: to evaluate whether the early metabolic response, assessed by 18F-fluoro-deoxyglucose positron emission-computed tomography (18F-FDG PET-CT), could predict the prognosis in LA-NSCLC patients treated with a multimodal approach, including IC-LDRT.