Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review

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• 作者：Larissa Paixão ; Ramon B. Ramos ; Anita Lavarda…
• 关键词：Animal models ; Ovary ; PCOS ; Androgens ; Estrogens ; Transgenic animals ; Rodents ; Non ; human primates
• 刊名：Reproductive Biology and Endocrinology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：626KB
• 刊物主题：Reproductive Medicine; Endocrinology;
• 出版者：BioMed Central
• ISSN：1477-7827
• 卷排序：15

文摘

Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9–18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovulation. The etiology of PCOS is still poorly known, and information from experimental animal models may help improve current understanding of the mechanisms of PCOS initiation and development. Therefore, we conducted a systematic review of currently available methods for simulation of PCOS in experimental models, focusing on two main endocrine traits: ovarian morphology changes and circulating levels of sex hormones and gonadotropins.