Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae

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• 作者：Maria C. Zarcone ; Annemarie van Schadewijk ; Evert Duistermaat…
• 关键词：Airway epithelial cells ; Diesel exhaust ; Air pollution ; COPD ; Non ; typeable Haemophilus influenzae ; Integrated stress response ; Antimicrobial response ; Antimicrobial peptides
• 刊名：Respiratory Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：803KB
• 刊物主题：Pneumology/Respiratory System;
• 出版者：BioMed Central
• ISSN：1465-993X
• 卷排序：18

文摘

BackgroundExacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus influenzae (NTHi), and exposures to diesel engine emissions are known to contribute to exacerbations in COPD patients. However, the effect of diesel exhaust (DE) exposure on the epithelial response to microbial stimulation is incompletely understood, and possible differences in the response to DE of epithelial cells from COPD patients and controls have not been studied.