In vitro generation of Sertoli-like and haploid spermatid-like cells from human umbilical cord perivascular cells

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• 作者：Ekaterina Shlush ; Leila Maghen ; Sonja Swanson…
• 关键词：Ex ; vivo spermatogenesis ; Germ cell ; Sertoli cell ; Spermatogonial stem cell ; Niche ; Human mesenchymal stem cell ; Perivascular cell ; Human umbilical cord ; Xenograft ; Paracrine
• 刊名：Stem Cell Research & Therapy
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：2787KB
• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512
• 卷排序：8

文摘

BackgroundFirst trimester (FTM) and term human umbilical cord-derived perivascular cells (HUCPVCs), which are rich sources of mesenchymal stem cells (MSCs), can give rise to Sertoli cell (SC)-like as well as haploid germ cell (GC)-like cells in vitro using culture conditions that recapitulate the testicular niche.