Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation

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• 作者：Payel Sil ; Haley Wicklum ; Chandler Surell ; Balázs Rada
• 关键词：Neutrophil extracellular traps (NETs) ; Interleukin ; 1 beta ; Macrophage ; Gout
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：66
• 期：3
• 页码：227-237
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

Objective and designArthritic gout is caused by joint inflammation triggered by the damaging effects of monosodium uric acid (MSU) crystal accumulation in the synovial space. Neutrophils play a major role in mediating joint inflammation in gout. Along with neutrophils, other immune cells, such as macrophages, are present in inflamed joints and contribute to gout pathogenesis. Neutrophils form neutrophil extracellular traps (NETs) in response to MSU crystals. In the presence of MSU crystals, macrophages release IL-1β, a cytokine crucial to initiate gout pathogenesis and neutrophil recruitment. Our research investigated interactions between human macrophages and neutrophils in an in vitro model system and asked how macrophages affect NET formation stimulated by MSU crystals.