Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

详细信息    查看全文

• 作者：Wei Chen ; Minjie Zhao ; Shuzhi Zhao ; Qianyi Lu ; Lisha Ni ; Chen Zou…
• 关键词：NLRP3 inflammasome ; Diabetic retinopathy ; Minocycline
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：66
• 期：2
• 页码：157-166
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

Objective and designChronic low-grade inflammation occurs in diabetic retinopathy (DR), but the underlying mechanism(s) remains (remain) unclear. NLRP3 inflammasome activation is involved in several other inflammatory diseases. Thus, we investigated the role of the NLRP3 inflammasome signaling pathway in the pathogenesis of DR.