NLRP3 inflammasome: a promising target in ischemic stroke

详细信息    查看全文

• 作者：Li Gao ; Qing Dong ; Zhenghong Song ; Fei Shen ; Jianquan Shi…
• 关键词：NLRP3 inflammasome ; Ischemic stroke ; Pathogenesis ; Treatment
• 刊名：Inflammation Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：1
• 页码：17-24
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Immunology; Pharmacology/Toxicology; Rheumatology; Allergology; Dermatology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1420-908X
• 卷排序：66

文摘

BackgroundRecently, several studies have demonstrated that the NLRP3 inflammasome participates in detecting cellular damage and mediating inflammatory responses to aseptic tissue injury following cerebral ischemia. More importantly, blocking or inhibiting NLRP3 inflammasome at multiple levels, such as its expression, assembly and activity, may offer substantial promise to salvage neurological deterioration during ischemic stroke. However, the specific mechanisms about the contribution of NLRP3 to neurovascular damage remain to be established.