Expression of an immunogenic LTB-based chimeric protein targeting Zaire ebolavirus epitopes from GP1 in plant cells

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• 作者：Regina Ríos-Huerta ; Elizabeth Monreal-Escalante…
• 关键词：Heat ; labile enterotoxin ; Zaire ebolavirus ; Transmucosal carrier ; Humoral response ; Plant ; based vaccine ; Systemic and mucosal antibodies
• 刊名：Plant Cell Reports
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：36
• 期：2
• 页码：355-365
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Plant Sciences; Cell Biology; Biotechnology; Plant Biochemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-203X
• 卷排序：36

文摘

Key messageAn antigenic protein targeting two epitopes from theZaire ebolavirusGP1 protein was expressed in plant cells rendering an antigen capable of inducing humoral responses in mouse when administered subcutaneously or orally.