Ischemic Preconditioning-Induced SOCS-1 Protects Rat Intestinal Ischemia Reperfusion Injury via Degradation of TRAF6

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• 作者：Sheng-zhi Liu ; Xue-mei He ; Xu Zhang ; Fan-cai Zeng…
• 关键词：Intestinal ischemia–reperfusion ; Ischemic preconditioning ; Tumor necrosis factor receptor ; associated factor 6 ; Cell signaling inhibition of apoptosis factor 1 ; Apoptosis
• 刊名：Digestive Diseases and Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：62
• 期：1
• 页码：105-114
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general;
• 出版者：Springer US
• ISSN：1573-2568
• 卷排序：62

文摘

BackgroundThe inflammatory immune response plays an important role in mesenteric ischemia and ischemia–reperfusion injury. Toll-like receptor 4 (TLR4) is a critical receptor in transduction of the inflammatory response and plays an important role in intestinal homeostasis. Tumor necrosis factor receptor-associated factor 6 (TRAF6), known as a key adaptor protein downstream of TLR4, is involved in the inflammatory response by activating multiple apoptotic signaling pathways. However, mechanisms of the suppressor of cytokine signaling-1 (SOCS-1) in regulating cell inflammation and apoptosis are still obscure.