Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer

详细信息    查看全文

• 作者：Ding Ma ; Yi-Zhou Jiang ; Xi-Yu Liu ; Yi-Rong Liu…
• 关键词：Intra ; tumor genetic heterogeneity ; Mutant ; allele tumor heterogeneity ; The Cancer Genome Atlas ; Breast cancer ; MYC
• 刊名：Breast Cancer Research and Treatment
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：162
• 期：1
• 页码：39-48
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology;
• 出版者：Springer US
• ISSN：1573-7217
• 卷排序：162

文摘

PurposeIntra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data.