Up-regulation of cathepsin S expression by HSP90 and 5-HT₇ receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer

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• 作者：Jaya Gautam ; Young Kyung Bae ; Jung-Ae Kim
• 关键词：Triple ; negative breast cancer ; Cathepsin S ; 5 ; HT7 ; HSP90 ; Invasion/metastasis
• 刊名：Breast Cancer Research and Treatment
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：161
• 期：1
• 页码：29-40
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology;
• 出版者：Springer US
• ISSN：1573-7217
• 卷排序：161

文摘

PurposeCathepsin S (CTSS) is expressed in a variety of cancers and stimulates tumor progression. However, the regulatory mechanism and role of CTSS in breast cancer progression are poorly understood. The aim of this study was to examine the relationships between CTSS expression and breast cancer grade and stage, and the signaling molecules involved in CTSS expression.