Synthesis and antibacterial activity screening of quaternary ammonium derivatives of triazolyl pyranochromenones

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• 作者：PREETI YADAV ; BIPUL KUMAR ; HEMANT K GAUTAM ; SUNIL K SHARMA
• 关键词：Quaternary ammonium derivatives ; triazolyl pyranochromen ; 2 ; ones ; antibacterial activity ; structure ; activity relationship (SAR).
• 刊名：Journal of Chemical Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：129
• 期：2
• 页码：211-222
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry/Food Science, general;
• 出版者：Springer India
• ISSN：0973-7103
• 卷排序：129

文摘

A series of quaternary ammonium derivatives of triazolyl pyranochromen-2-ones have been synthesized and characterized; their antibacterial potential were investigated against two gram negative (Pseudomonas aeruginosa and Escherichia coli) and two gram positive bacterial strains (Bacillus cereus and Staphylococcus aureus). In order to develop structure-activity relationship (SAR), the effect of varying the substituent (R) at the C-10 position of pyranochromen-2-one as well as the length of the spacer (n) between the triazolyl pyranochromen-2-ones and quaternary ammonium group, on the antibacterial activity of compounds has been evaluated. Some of the screened compounds exhibited antibacterial potential against the studied strains in the microgram range.