Thermal activities of 6-gingerol, 8-gingerol and 6-shogaol on the potentiation of mitochondria thermogenesis based on microcalorimetry

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• 作者：Zhirui Yang ; Dingkun Zhang ; Yaming Zhang…
• 关键词：6 ; Gingerol ; Thermal activity ; Mitochondria thermogenesis ; Microcalorimetry
• 刊名：Journal of Thermal Analysis and Calorimetry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：127
• 期：2
• 页码：1787-1795
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Physical Chemistry; Analytical Chemistry; Polymer Sciences; Inorganic Chemistry; Measurement Science and Instrumentation;
• 出版者：Springer Netherlands
• ISSN：1588-2926
• 卷排序：127

文摘

Zingiberis Rhizoma is a typical Chinese herb in ‘hot’ property. Nowadays, increasing attention has been aroused for its essential role in both health care and treatment of ‘cold’ syndrome. And research about characteristics of Zingiberis Rhizoma is able to provide an important reference for its deeper understand and successful clinic application. However, cognition level about the ‘hot’ property of Zingiberis Rhizoma is superficial, and mechanism behind the ‘hot’ presentation is still elusive and unclear. In this study, the ‘hot’ property of Zingiberis Rhizoma was investigated at a monomer level with assistance of microcalorimetry, an objective and sensitive method in evaluating biological activity. Three bioactive compounds including 6-gingerol, 8-gingerol and 6-shogaol were selected, and their thermal activities were explored with mitochondria as target. The power–time curves were recorded, and five thermal parameters (k, P_max, T_max, Q and P_av) were obtained. With PCA, P_av was calculated to be the main parameter to measure the bioactivities of 6-gingerol, 8-gingerol and 6-shogaol. Finally, the bioactivities of three subjects were compared with sequence to be 6-gingerol > 8-gingerol > 6-shogaol. Generally, our study is promising to offer a reference to the research about characteristics of Zingiberis Rhizoma or other herbs and is of great interest for clinic practice.