Identification and characterization of the glucose dual-affinity transport system in Neurospora crassa: pleiotropic roles in nutrient transport, signaling, and carbon catabolite repression

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• 作者：Bang Wang ; Jingen Li ; Jingfang Gao ; Pengli Cai ; Xiaoyun Han…
• 关键词：Glucose transporter ; Dual ; affinity ; GLT ; 1 ; HGT ; 1/ ; 2 ; Cellulase ; Signaling
• 刊名：Biotechnology for Biofuels
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：13485KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Biotechnology; Plant Breeding/Biotechnology; Environmental Engineering/Biotechnology; Renewable and Green Energy; Renewable and Green Energy; Microbiology;
• 出版者：BioMed Central
• ISSN：1754-6834
• 卷排序：10

文摘

BackgroundThe glucose dual-affinity transport system (low- and high-affinity) is a conserved strategy used by microorganisms to cope with natural fluctuations in nutrient availability in the environment. The glucose-sensing and uptake processes are believed to be tightly associated with cellulase expression regulation in cellulolytic fungi. However, both the identities and functions of the major molecular components of this evolutionarily conserved system in filamentous fungi remain elusive. Here, we systematically identified and characterized the components of the glucose dual-affinity transport system in the model fungus Neurospora crassa.