Display of single-chain variable fragments on bacteriophage MS2 virus-like particles

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• 作者：Christopher A. Lino ; Jerri C. Caldeira ; David S. Peabody
• 关键词：Virus ; like particles ; Phage display ; Single ; chain antibodies ; Bacteriophage MS2
• 刊名：Journal of Nanobiotechnology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：1927KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Biotechnology; Nanotechnology; Molecular Medicine;
• 出版者：BioMed Central
• ISSN：1477-3155
• 卷排序：15

文摘

BackgroundVirus-like particles (VLPs) of the RNA bacteriophage MS2 have many potential applications in biotechnology. MS2 VLPs provide a platform for peptide display and affinity selection (i.e. biopanning). They are also under investigation as vehicles for targeted drug delivery, using display of receptor-specific peptides or nucleic acid aptamers to direct their binding to specific cell-surface receptors. However, there are few molecules more suited to the precise targeting and binding of a cellular receptor than antibodies.