Oleic acid incorporated gemcitabine-eluting stents for treatment of cholangiocarcinoma

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• 作者：Jeongdeok Seo ; Jonghwan Lee ; Kun Na
• 关键词：drug eluting stent ; penetration enhancer ; cholangiocarcinoma ; gemcitabine ; therapeutic effect
• 刊名：Macromolecular Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：63-69
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Physical Chemistry; Characterization and Evaluation of Materials; Nanochemistry; Nanotechnology;
• 出版者：The Polymer Society of Korea
• ISSN：2092-7673
• 卷排序：25

文摘

One of the major issues in cholangiocarcinoma (CC) treatment is bile duct occlusion-associated symptoms. As an alternative way of surgical excision of a CC, drug-eluting stents (DESs) have developed to treat both CC and occlusion. Gemcitabine (Gem) is effective for treatment of CC, however, it has limited applicability to use in DES because of its hydrophilic property. To solve these problems, we developed stent coating membrane (PTOA10-Gem) consisted of Gem, oleic acid (OA), and pellethane (PT). PTOA10-Gem membranes were additionally coated with PT to minimize rapid initial burst and washout of water-soluble Gem. OA was incorporated as a tissue penetration enhancer, and successfully achieved enhanced Gem penetration into cancer cell sheet (5.25-fold) and mouse skin (3- fold). Moreover, PTOA10-Gem led to dramatic decrease in tumor volume by 45% for 9 days. These findings suggest that the OA incorporated PT membrane is effective to improve a therapeutic efficacy of hydrophilic drug-eluting stents to treat CC, as well as other non-vascular cancers.