High-cholesterol diet does not alter gut microbiota composition in mice

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• 作者：Lidiya G. Dimova ; Nikola Zlatkov ; Henkjan J. Verkade…
• 关键词：Diet ; Cholesterol ; microbiota ; Ldlr ; knockout ; Bile ; Neutral sterols
• 刊名：Nutrition & Metabolism
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：562KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Clinical Nutrition; Metabolic Diseases;
• 出版者：BioMed Central
• ISSN：1743-7075
• 卷排序：14

文摘

IntroductionWestern diet containing both saturated fat and cholesterol impairs cardio-metabolic health partly by modulating diversity and function of the microbiota. While diet containing only high fat has comparable effects, it is unclear how diets only enriched in cholesterol impact the microbiota. Therefore, we aimed to characterize the response of host and microbiota to a high cholesterol (HC) diet in mice susceptible to cardio-metabolic disease.