Association of interleukin-18 and asthma

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• 作者：Ming-Hui Xu ; Feng-Lai Yuan ; Shu-Jing Wang ; Hui-Ying Xu ; Cheng-Wan Li…
• 关键词：KEY WORDSIL ; 18 ; Asthma ; Th1 cell ; Th2 cell
• 刊名：Inflammation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：1
• 页码：324-327
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Rheumatology; Internal Medicine; Pharmacology/Toxicology; Pathology;
• 出版者：Springer US
• ISSN：1573-2576
• 卷排序：40

文摘

Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity. IL-18 can act as a cofactor for Th2 cell development and IgE production and also plays an important role in the differentiation of Th1 cells. Recent work identified an IL-18 association with the pathogenesis of asthma, wherein increased IL-18 expression was found in the serum of patients. Furthermore, IL-18 polymorphisms with susceptibility to asthma were reported, suggesting that IL-18 may be therapeutically relevant to asthma. In this review, we discuss the role of IL-18 in the pathogenesis of asthma and its therapeutic potential based on current research.