Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption

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• 作者：Kathleen Panter Faber ; Hsin-Fang Wu ; Marc R. Yago ; Xiaohui Xu…
• 关键词：KEY WORDSabsorption ; atazanavir ; food effects ; PPIs ; weakly basic drugs
• 刊名：Pharmaceutical Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：34
• 期：3
• 页码：619-628
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
• 出版者：Springer US
• ISSN：1573-904X
• 卷排序：34

文摘

PurposeClinically relevant pharmacokinetic interactions exist between gastric acid-reducing agents and certain weakly basic drugs that rely on acidic environments for optimal oral absorption. In this study, we examine whether the administration of betaine hydrochloride under fed conditions can enhance the absorption of atazanavir, an HIV-1 protease inhibitor, during pharmacologically-induced hypochlorhydria.