Synthesis and characterization of magnetic mesoporous core–shell nanocomposites for targeted drug delivery applications

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• 作者：Wei Jiang ; Juan Wu ; Renbing Tian ; Wei Jiang
• 关键词：Magnetic nanocomposites ; Mesoporous silica ; pH ; sensitive ; Cancer therapy
• 刊名：Journal of Porous Materials
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：24
• 期：1
• 页码：257-265
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Catalysis; Characterization and Evaluation of Materials; Physical Chemistry;
• 出版者：Springer US
• ISSN：1573-4854
• 卷排序：24

文摘

Magnetic mesoporous nanocomposites are emerging as a significant new material to improve the effectiveness of cancer treatment and enhance the availability of drug therapy. Thus, the core–shell structure magnetic mesoporous nanocomposites (Fe₃O₄@SiO₂@LDH) were synthesized with an average diameter of about 100 nm and used as methotrexate (MTX) carriers for cancer therapy. As an important biological material, Fe₃O₄@SiO₂@LDH exhibited higher superparamagnetic behavior and biocompatibility, and the drugs can be loaded in the channels of the mesoporous silica and the interlayer of layered double hydroxides (LDH). The embedding rate of magnetic mesoporous silica (Fe₃O₄@SiO₂) and LDH were 60.32 % and 0.67 %, respectively, and the release rate of the drug delivery systems (Fe₃O₄@SiO₂@LDH-MTX) was 66.81 %. In addition, LDH as a kind of pH-sensitive material was adopted for controlled drug release and WST-1 assays in cancer cells (Hela) demonstrated that Fe₃O₄@SiO₂@LDH-MTX presented high anti-tumor activity, while the carriers were nearly non-toxic. Therefore, all the results suggested that the magnetic nanocomposites can be employed to deliver MTX, and would be applied in the field of cancer therapy in the future.