Antimicrobial Stewardship and Environmental Decontamination for the Control of Clostridium difficile Transmission in Healthcare Settings

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• 作者：Jason Bintz ; Suzanne Lenhart ; Cristina Lanzas
• 关键词：Clostridium difficile ; Control ; Agent ; based model
• 刊名：Bulletin of Mathematical Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：79
• 期：1
• 页码：36-62
• 全文大小：
• 刊物类别：Mathematics and Statistics
• 刊物主题：Mathematical and Computational Biology; Life Sciences, general; Cell Biology;
• 出版者：Springer US
• ISSN：1522-9602
• 卷排序：79

文摘

We implement an agent-based model for Clostridium difficile transmission in hospitals that accounts for several processes and individual factors including environmental and antibiotic heterogeneity in order to evaluate the efficacy of various control measures aimed at reducing environmental contamination and mitigating the effects of antibiotic use on transmission. In particular, we account for local contamination levels that contribute to the probability of colonization and we account for both the number and type of antibiotic treatments given to patients. Simulations illustrate the relative efficacy of several strategies for the reduction of nosocomial colonizations and nosocomial diseases.