Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome

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• 作者：Félix Javier Jiménez-Jiménez ; Elena García-Martín…
• 关键词：Genetics ; HNMT gene ; Polymorphisms ; Restless legs syndrome ; Risk factors
• 刊名：Journal of Neural Transmission
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：124
• 期：3
• 页码：285-291
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Neurology; Psychiatry; Pharmacology/Toxicology; Neurosciences;
• 出版者：Springer Vienna
• ISSN：1435-1463
• 卷排序：124

文摘

A recent meta-analysis suggests an association between the rs11558538 single nucleotide polymorphism in the histamine-N-methyl-transferase (HNMT) gene and the risk for Parkinson’s disease. Based on the possible relationship between PD and restless legs syndrome (RLS), we tried to establish whether rs11558538 SNP is associated with the risk for RLS. We studied the genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 RLS patients and 410 healthy controls using a TaqMan assay. The frequencies of the HNMT rs11558538 genotypes allelic variants were similar between RLS patients and controls, and were not influenced by gender, family history of RLS, or RLS severity. RLS patients carrying the genotype rs11558538TT had an earlier age at onset, but this finding was based on three subjects only. These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS.