In vitro chondrocyte toxicity following long-term, high-dose exposure to Gd-DTPA and a novel cartilage-targeted MR contrast agent

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• 作者：Sharon Midura ; Erika Schneider ; Gerald M. Rosen ; Carl S. Winalski…
• 关键词：Cartilage ; MRI ; Contrast agent ; Gd ; DTPA ; Cytotoxicity ; Dendrimer ; Gadolinium ; Biochemistry
• 刊名：Skeletal Radiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：23-33
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Imaging / Radiology; Orthopedics; Pathology; Nuclear Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2161
• 卷排序：46

文摘

ObjectiveTo determine the concentrations exhibiting toxicity of a cartilage-targeted magnetic resonance imaging contrast agent compared with gadopentetate dimeglumine (Gd-DT-PA) in chondrocyte cultures.