Primary wound closure after tooth extraction for prevention of medication-related osteonecrosis of the jaw in patients under denosumab

详细信息    查看全文

• 作者：Akihiko Matsumoto ; Masanori Sasaki ; Rainer Schmelzeisen…
• 关键词：Osteonecrosis of the jaw ; Tooth extraction ; Denosumab ; Prevention ; MRONJ
• 刊名：Clinical Oral Investigations
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：127-134
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Dentistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1436-3771
• 卷排序：21

文摘

ObjectivesSome recent reports have indicated that local infection causes osteonecrosis of the jaw and described that tooth extraction may not be a direct cause of developing medication-related osteonecrosis of the jaw (MRONJ) in patients receiving antiresorptive medications. Tooth extraction and elimination of the source of infection are expected to reduce the risk of developing MRONJ. However, there is no data regarding prevention for developing osteonecrosis of the jaw in patients receiving denosumab. Therefore, the aim of this study was to investigate the outcome of tooth extractions with proper wound closure in patients receiving denosumab.