Assessment of urinary microparticles in normotensive patients with type 1 diabetes

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• 作者：Yuliya Lytvyn ; Fengxia Xiao ; Christopher R. J. Kennedy ; Bruce A. Perkins…
• 关键词：Albuminuria ; Biomarker ; Diabetes ; Extracellular vesicle ; Hyperglycaemia ; Microparticle ; Microvesicle ; Podocyte
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：60
• 期：3
• 页码：581-584
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisAssessment of urinary extracellular vesicles including exosomes and microparticles (MPs) is an emerging approach for non-invasive detection of renal injury. We have previously reported that podocyte-derived MPs are increased in diabetic mice in advance of albuminuria. Here, we hypothesised that type 1 diabetes and acute hyperglycaemia would increase urinary podocyte MP levels in uncomplicated diabetes.